Author's response to reviews Title:Biomarker discovery: Quantification of microRNAs and other small non-coding RNAs using next generation sequencing Authors:
نویسندگان
چکیده
Juan Pablo Lopez ([email protected]) Alpha Diallo ([email protected]) Cristiana Cruceanu ([email protected]) Laura M. Fiori ([email protected]) Sylvie Laboissiere ([email protected]) Isabelle Guillet ([email protected]) Joelle Fontaine ([email protected]) Jiannis Ragoussis ([email protected]) Vladimir Benes ([email protected]) Gustavo Turecki ([email protected]) Carl Ernst ([email protected])
منابع مشابه
Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing.
Small non-coding RNAs, such as microRNAs (miRNAs), are involved in diverse processes, including organ development and tissue differentiation. Exosomes are small membrane vesicles (30-100 nm in diameter) produced by numerous cells. Recently, exosomes have been shown to contain miRNAs. However, the small RNAs contained in exosomes are not fully characterized. In a previous study, we found at leas...
متن کاملSmall RNA Profile in Moso Bamboo Root and Leaf Obtained by High Definition Adapters
Moso bamboo (Phyllostachy heterocycla cv. pubescens L.) is an economically important fast-growing tree. In order to gain better understanding of gene expression regulation in this important species we used next generation sequencing to profile small RNAs in leaf and roots of young seedlings. Since standard kits to produce cDNA of small RNAs are biased for certain small RNAs, we used High Defini...
متن کاملPhysiological and Pathological Roles for MicroRNAs: Implications for Immunity Complications
MicroRNAs (miRNAs) are small non-coding regulatory RNAs molecules with a size of approximately 22 nucleotides that are implicated in regulating gene expression at the post-transcriptional regulatory levels. Inflammatory disorders especially autoimmune diseases (ADs) occur from an abnormal immune response of body against cells of their own specific tissues or multiple organ systems leading to ch...
متن کاملExploring ncRNAs in Alzheimer’s disease by miRMaster
Circulating biomarkers for the diagnosis of Alzheimer’s Disease (AD) such as amyloid-β levels are already applied in clinical care. New markers, especially marker panels that can be measured from blood and specifically focusing at early diagnosis, are under development [1]. Previously, we published miRNA signatures in Alzheimer’s Disease that have been discovered by high-throughput sequencing (...
متن کاملDiscovery of Novel MicroRNAs in Rat Kidney Using Next Generation Sequencing and Microarray Validation
MicroRNAs (miRNAs) are small non-coding RNAs that regulate a variety of biological processes. The latest version of the miRBase database (Release 18) includes 1,157 mouse and 680 rat mature miRNAs. Only one new rat mature miRNA was added to the rat miRNA database from version 16 to version 18 of miRBase, suggesting that many rat miRNAs remain to be discovered. Given the importance of rat as a m...
متن کامل